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Chemistry

Macromolecules

3,366 words, 10 sections. The first two are free.

The opening sections

Definitions first, then the reasoning. Each section is short enough to read in one sitting.

This chapter covers the chemistry of very large molecules, and it has 218 distinct questions across 75 official papers between 2000 and 2026. The weight is uneven: protein classification and structure alone accounts for 115 of those questions, carbohydrates and lipids 69, and enzymes as biocatalysts 33. A student who masters it can name a polymer and its monomer, tell addition from condensation polymerisation, classify a protein by composition and by function, describe the four levels of protein structure, and match a sugar, a base or an enzyme to its role.

A macromolecule is a molecule large enough that its size, not its functional groups, dominates its behaviour, and the usual way to build one is to join many small units. The repeating unit is the monomer and the large molecule is the polymer, so a polymer is a monomer written many times over. Ethene polymerises to polythene, written with the repeating unit in brackets and nn monomers consumed:

nCH2=CH2→100 atm, 400∘C[CH2−CH2]nn\text{CH}_2=\text{CH}_2 \xrightarrow{100\ \text{atm},\ 400^\circ\text{C}} [\text{CH}_2-\text{CH}_2]_n

The idea reaches past plastics. Starch is a polymer of α\alpha-D-glucose, a protein is a polymer of amino acids joined by peptide bonds, and chlorophyll, the pigment of photosynthesis, is a naturally occurring macromolecule built round a single Mg2+\text{Mg}^{2+} ion. The distinction that matters is origin and route: some macromolecules are natural and some synthetic, and the synthetic ones are the ones whose monomers you are expected to name.

8 more sections in this chapter

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